Connectivity Map. Connectivity Atlas Vivid Maps But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries. The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them
Connectivity map of the selected variables represented as a "Minimum from www.researchgate.net
Such a catalog of connections could serve as a functional look-up table of the genome; we termed this concept the Connectivity Map (CMap) We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures
Connectivity map of the selected variables represented as a "Minimum
To build a Connectivity Map, the Broad brings together molecular biologists, genomics specialists, computational scientists, pharmacologists, chemists and chemical biologists, as well as expertise from across the breadth and depth of. The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them To date, CMap has generated a library containing over 1.5M gene expression profiles from ~5,000 small-molecule compounds, and ~3,000 genetic reagents, tested in multiple cell types
web mapping Examples of geovisualizations of global connectivity. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs This web interface is designed to allow biologists.
Mechanistic overview of the Connectivity Map (CMAP). Download. But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries. We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures